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Vacancy Excellence Program

Our Research focuses on the elucidation of the molecular mechanisms underlying hormonal-mediated regulation of solute and water transport processes in epithelia including kidney and small intestine. The major emphasis is currently on the epithelial calcium (TRPV5 & TRPV6), magnesium (TRPM6 & TRPM7) and water (Aquaporin 2) channels, salt transporters (NCC, ENaC) and succinate receptors that constitute instrumental solute transport pathways in epithelia. The current projects aim to investigate in detail the regulation of these transport activities in health and disease. To this end, a wide variety of cutting edge techniques are applied including cell and molecular biological, genetics biochemical and physiological procedures.

What we are looking for:

  • A background in (molecular) renal physiology
  • High affinity for research in (molecular) life sciences, health (services) research or public health
  • Excellent junior researchers (guideline untill 12 years after PhD promotion) with a strong motivation to perform top internationally-recognised research
  • A proven track record (e.g. publications, research funding) with preferred international experience
  • Excellent interpersonal and communication skills and with the strong wish to work interdisciplinary

What do we offer?

Radboud PostDoc Fellowships are available. Several awards are available each year with deadlines (deadlines of application 1st May or 1st November). Fellowships are intended for researchers who received their doctorate between two and twelve years ago. More information about this special program click here. The department of Physiology welcomes applicants in the field of Renal Physiology and will coach the interested applicants during the application process.

Want to know more?

Please contact Prof. René Bindels

René Bindels is as physiologist interested in the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular. In addition, the functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia are investigated. The studies include use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity. He is responsible for several physiology courses for medical and health science students. He is an elected member of the Academia Europaea and recipient of the Robert Pitts Lectureship of the International Union of Physiological Sciences, Carl W. Gottschalk Lectureship of the American Physiological Society and Homer Smith award of the American Society of Nephrology. Since 2010 he is the scientific director of the Radboud Institute for Molecular Life Sciences (RIMLS).

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